Technology

  • DNA Encoded Library (DEL) is an innovative drug discovery technology rapidly gaining wide spread interest in the pharmaceutical industry in recent years. It combines the power of molecular biology, combinatorial chemistry, high throughput sequencing and advanced informatics to create vast number of novel molecules for hit identification and lead generation. HitGen has been building a large collection of novel, diverse and drug-like DELs as its primary drug discovery platform.


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Pipeline

  • Currently HitGen has more than 20 internal projects in research, with 1 in Phase I, 2 in PCC generation and 2 in lead generation,mainly focused on oncology, CVD, inflammation/ respiratory, metabolism and ophthalmology.
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Target Project Progress Therapeutic Area
Target: Deacetylase Target: Phosphatase Target: Dehydrogenase Target: Dioxygenase Target: Kinase Target: Protease Target: Lipase Target: Methyltransferase Target: GPCR Target:  Protein Protein Interaction Project progress: Target Preparation Project progress: Target Screening Project progress: Hit Validation Project progress: Hit2Lead Optimization Project progress: Lead Optimization Project progress: PCC generation Therapeutic Area: Ophthalmology Therapeutic Area: Metabolism Therapeutic Area: Inflammation/Respiratory Therapeutic Area: Cardiovascular Therapeutic Area: Oncology
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Partnering

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    DNA Encoded Library Screening
    HitGen will screen its most up to date proprietary DELs (hundreds of billions of novel small molecules and macrocycles) against targets provided by the partners.
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    Custom DNA Encoded Library Synthesis
    HitGen will be responsible for the design and synthsis of DNA encoded library base on partner's specification. 
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    Innovative Drug Project Collaboration

    HitGen initiates a number of innovative drug discovery projects. These projects can be the subject of collaboration, which cover the areas of oncology, CVD, inflammation/ respiratory, metabolism and ophthalmology.


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  • Careers

  • Here, we build future together! 

    Here, we create innovative medicine for patients!

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